- Title
- Association between hypertension and chronic arsenic exposure in drinking water: a cross-sectional study in Bangladesh
- Creator
- Islam, Mohammad Rafiqul; Khan, Ismail; Hasnat, Abul Hasnat; Attia, John; Hassan, Sheikh Mohammad Nazmul; McEvoy, Mark; D'Este, Catherine; Azim, Syed; Akhter, Ayesha; Akter, Shahnaz; Shahidullah, Sheikh Mohammad
- Relation
- International Journal of Environmental Research and Public Health Vol. 9, Issue 12, p. 4522-4536
- Publisher Link
- http://dx.doi.org/10.3390/ijerph9124522
- Publisher
- MDPI
- Resource Type
- journal article
- Date
- 2012
- Description
- Chronic arsenic exposure and its association with hypertension in adults are inconclusive and this cross-sectional study investigated the association. The study was conducted between January and July 2009 among 1,004 participants from 1,682 eligible women and men aged ≥30 years living in rural Bangladesh who had continuously consumed arsenic-contaminated drinking water for at least 6 months. Hypertension was defined as systolic blood pressure ≥140 mmHg (systolic hypertension) and diastolic blood pressure ≥90 mmHg (diastolic hypertension). Pulse pressure was calculated by deducting diastolic from systolic pressure and considered to be increased when the difference was ≥55 mmHg. The prevalence of hypertension was 6.6% (95% CI: 5.1–8.3%). After adjustment for other factors, no excess risk of hypertension was observed for arsenic exposure >50μg/L or to that of arsenic exposure as quartiles or as duration. Arsenic concentration as quartiles and >50 μg/L did show a strong relationship with increased pulse pressure (adjusted OR: 3.54, 95% CI: 1.46–8.57), as did arsenic exposure for ≥10 years (adjusted OR: 5.25, 95% CI: 1.41–19.51). Arsenic as quartiles showed a dose response relationship with increased pulse pressure. Our study suggests an association between higher drinking water arsenic or duration and pulse pressure, but not hypertension.
- Subject
- arsenic; drinking-water; hypertension; pulse-pressure; Bangladesh
- Identifier
- http://hdl.handle.net/1959.13/1300543
- Identifier
- uon:20106
- Identifier
- ISSN:1661-7827
- Language
- eng
- Full Text
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